soluble her-2 in patients with head and neck squamous cell carcinoma
Authors
abstract
introduction: the presence of her-2 has been shown to be a prognostic factor in many kinds of cancers, but its role in head and neck squamous cell carcinoma (hnscc) is not still defined. the purpose of the current study is to investigate the role of her-2 in hnscc and its correlation with various clinicopathologic parameters. materials and methods: peripheral blood samples were obtained from 17 healthy volunteers and 69 patients with hnscc before curative surgery. the her-2 level was determined in each sample by sandwich elisa. statistical analysis was performed using an independent t-test, one-way anova, and mann-whitney test. results: mean her-2 serum levels in patients with hnscc compared with healthy controls was not statistically significant (3.85ng/ml vs. 3.75ng/ml; p>0.05). the mean serum level of her-2 was higher in patients with lymph node involvement, metastasis, invasion, tumor size ≥2 cm, and stage>1, although the differences were not statistically significant (p>0.05). discussion: mean her-2 serum levels in patients with tumor size t3 and higher were greater than those from patients in stage t1 and t2, a finding which may be translated into disease progression, growth and invasiveness. conclusion: in this study the mean her-2 serum level in patients with hnscc was found statistically insignificant compared with the healthy control group. the role of soluble her-2 as a tumor marker is still controversial and needs further studies to clarify its clinical relevance for early detection or screening for hnscc.
similar resources
Soluble HER-2 in Patients with Head and Neck Squamous Cell Carcinoma
Introduction: The presence of HER-2 has been shown to be a prognostic factor in many kinds of cancers, but its role in head and neck squamous cell carcinoma (HNSCC) is not still defined. The purpose of the current study is to investigate the role of HER-2 in HNSCC and its correlation with various clinicopathologic parameters. Materials and Methods: Peripheral blood samples were obtained ...
full textSoluble HER-2 in Patients with Head and Neck Squamous Cell Carcinoma
INTRODUCTION The presence of HER-2 has been shown to be a prognostic factor in many kinds of cancers, but its role in head and neck squamous cell carcinoma (HNSCC) is not still defined. The purpose of the current study is to investigate the role of HER-2 in HNSCC and its correlation with various clinicopathologic parameters. MATERIALS AND METHODS Peripheral blood samples were obtained from 17...
full textEvaluation of Tissue Expression and Salivary Levels of HER2/neu in Patients with Head and Neck Squamous cell Carcinoma
Introduction: HER2/neu, a member of the epidermal growth factor receptor family, has been shown to be over-expressed in some tumors. The purpose of this study was to determine the salivary levels and tissue expression of HER2/neu in patients with head and neck squamous cell carcinoma (HNSCC) and their correlation with clinicopathologic parameters. Materials and Methods: Enzyme-linked immu...
full textEpithelial-Mesenchymal Transition and Inflammation in Head and Neck Squamous Cell Carcinoma
Head and neck squamous cell carcinoma (HNSCC) represents a large majority of cancers arising from the head and neck, especially the oral cavity. Despite advances in therapy, the five-year survival rate remains low due to the number of patients presenting advanced stages of the disease. The role of epithelial-mesenchymal transition (EMT) in tumorigenesis in HNSCC remains unexplored. The current ...
full textIncidence of Etiologic Factors in Squamous Cell Carcinoma of Head and Neck in Ahvaz
Introduction: Squamous cell carcinoma (SCC) is the most common head and neck malignancy. Smoking, alcohol consumption, viral infections, exposure, oral hygiene, and dietary, genetic, and occupational factors are the most important etiologic factors. The aim of this study was determining the incidence of etiologic factors in head and neck SCC. Materials and Methods: This is a cross-sectiona...
full textDensity of mast-cells and Microvessels Density in head and neck cutaneous Squamous Cell Carcinoma
Background and Aim: Cutaneous squamous cell carcinoma (CSCC) is the second most common skin cancer. Mast cells may play a role in tumor progression and metastasis by increasing angiogenesis. The aim of this study was to investigate the role of mast cells by increasing angiogenesis in invasion of head and neck cutaneous squamous cell carcinoma. Materials and Methods: In this cross-sectional stud...
full textMy Resources
Save resource for easier access later
Journal title:
iranian journal of otorhinolaryngologyجلد ۲۵، شماره ۳، صفحات ۱۶۱-۱۶۷
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023